Medication: Rybelsus (Semaglutide)
Dosage: 14 mg, 7 mg, 3 mg
Price: from $15.00 per tablet
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Rybelsus (Semaglutide)

Diabetes mellitus is a chronic condition characterized by either insufficient insulin production by the pancreas (type 1 diabetes) or inadequate use of insulin by the body's tissues (type 2 diabetes). Insulin is a hormone essential for the utilization of glucose. In diabetes mellitus, as the name suggests, blood glucose levels rise significantly, becoming syrupy at high concentrations.

Type 2 diabetes typically arises from disturbances in carbohydrate metabolism, often linked to excess weight, obesity, and an unhealthy lifestyle. In this form of diabetes, insulin-dependent tissues such as muscles and the liver become less sensitive to insulin, resulting in elevated glucose levels in the blood and urine.

Recently, Rybelsus, a new medication for treating type 2 diabetes, was introduced to the pharmaceutical market.

Rybelsus is a hypoglycemic drug designed to control blood glucose levels and offers additional benefits, including:

  • Weight reduction
  • Decrease in adipose tissue
  • Appetite suppression
  • Reduced cravings for fatty foods

Due to these effects, some individuals have started using Rybelsus for weight loss purposes. However, this medication is not intended for weight loss in healthy individuals. Rybelsus is prescribed by doctors based on specific medical indications and is available at pharmacies only with a prescription.

Indications for Rybelsus

Rybelsus tablets are used to manage blood sugar levels in adults with type 2 diabetes, in conjunction with diet and exercise. It is prescribed as monotherapy for patients who cannot tolerate or are contraindicated for metformin. In more severe cases, Rybelsus may be used in combination with other hypoglycemic agents.

Rybelsus, containing semaglutide, can be taken alone or alongside other diabetes medications. The tablets should be swallowed whole with a glass of water, 30 minutes before taking other medications or having the first meal of the day.

The recommended starting dose is one 3 mg tablet per day for the first 30 days. After this period, your doctor may increase the dose to one 7 mg tablet per day. If necessary, the dose can be further adjusted to one 14 mg tablet per day after an additional 30 days, as directed by your doctor.

Contraindications

Rybelsus is contraindicated in the following conditions:

  • Type 1 diabetes mellitus: Rybelsus is not suitable for individuals with type 1 diabetes, as it is specifically designed for type 2 diabetes management.
  • Diabetic ketoacidosis: this condition, characterized by high levels of ketones in the blood leading to altered blood pH, is a contraindication for Rybelsus use.
  • History of thyroid cancer: Rybelsus is contraindicated in patients with a history of thyroid cancer, including those with a family history of this condition.
  • Multiple endocrine neoplasia (MEN) type 2: Rybelsus is not recommended for individuals with MEN type 2, a genetic disorder that affects endocrine glands.
  • Pregnancy and lactation: the safety of Rybelsus during pregnancy and breastfeeding has not been established, and it should be avoided in these conditions.
  • Children and adolescents: Rybelsus is not approved for use in individuals under 18 years of age.
  • Severe liver and kidney failure: patients with severe liver or kidney dysfunction should not use Rybelsus due to potential complications and altered drug metabolism.
  • Severe chronic heart failure: Rybelsus is contraindicated in individuals with severe chronic heart failure, as it may exacerbate existing heart conditions.

Additionally, caution is advised for individuals with any other significant health conditions, and Rybelsus should only be used under strict medical supervision in cases of borderline or moderate health issues.

Side effects

The following adverse reactions were observed in more than 10% of cases:

  • Hypoglycemia especially when used in combination with insulin or sulfonylurea derivatives.
  • Nausea
  • Diarrhea

In extremely rare cases, the following side effects were reported:

  • Hypoglycemia occurring with other hypoglycemic agents.
  • Loss of appetite
  • Complications of diabetic retinopathy
  • Vomiting
  • Constipation
  • Dyspepsia: indigestion or discomfort.
  • Pain, bloating, and flatulence
  • Gastritis- inflammation of the stomach lining.
  • Gastroesophageal reflux disease (GERD)
  • Fatigue

Rybelsus for weight loss

Rybelsus mimics the effects of GLP-1, a hormone naturally produced by the intestines after eating. This hormone signals the brain to induce feelings of fullness, thereby reducing hunger and supporting weight loss.

Rybelsus is generally prescribed for weight management in individuals with conditions such as type 2 diabetes, high blood pressure, dyslipidemia, or cardiovascular disease. For effective weight loss with Rybelsus, it is essential to combine the medication with regular physical activity and a healthy, balanced diet. Focus on consuming fresh fruits and vegetables, whole grains, lean proteins, legumes, and healthy fats to support your weight loss goals.